VALIDOGEN, formerly known as VTU Technology, is a leading Austrian contract research and development company. VALIDOGEN offers UNLOCK PICHIA - the broadest toolbox and most versatile technology platform available for Pichia pastoris recombinant protein production. Founded in 2008, the company emerged to a globally recognized player in the field of Pichia pastoris based protein expression. VALIDOGEN has established a broad range of tools and know-how for the generation of high-performance Pichia processes. Exclusive proprietary technologies and profound experience of the VALIDOGEN team lead to competitive production processes for a wide range of recombinant proteins. Headquartered in Raaba-Grambach, near Graz, Austria, VALIDOGEN is a private company and independent subsidiary of the KonValue Holding GmbH.
Production:UNLOCK PICHIA – World‘s broadest Pichia pastoris protein production platform UNLOCK PICHIA represents the broadest toolbox and most versatile technology platform available for Pichia pastoris recombinant protein production. We develop high performance expression strains and economically viable protein production processes for the competitive manufacture of biopharmaceuticals, enzymes and various other recombinant proteins serving different industries. UNLOCK PICHIA advantages • Numerous expression tools & different strategies • Targeted debottlenecking for yield maximization • Secreted products - beneficial starting point for protein purification • Complete absence of methanol through VALIDOGEN´s methanol-free promoters • Tailor-made glycoproteins - UNLOCK PICHIA boosting Pichia GlycoSwitch® • Stable, robust and scalable processes for commercial manufacturing
Services:Protein expression excellence VALIDOGEN develops customized high-performance Pichia pastoris protein production processes and offers straightforward production strain development as well as bioreactor cultivation & protein purification process development and optimization services. • Protein expression studies: Rapid assessment of expression potential, using streamlined and time saving feasibility studies • Comprehensive strain development: Targeted and time-saving generation of high-productivity strains already considering economic target values and regulatory requirements applying VALIDOGEN's broad UNLOCK PICHIA toolbox • Bioprocess development: Straightforward fermentation development, optimization and characterization services • Protein purification and DSP development: Protein purification and product characterization, broad toolbox of established analytical methods • Cell banking: Preparation and characterization of research cell banks • Enzyme engineering: High-throughput engineering and screening of enzyme variants